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Acute posterior multifocal placoid pigment epitheliopathy : ウィキペディア英語版 | Acute posterior multifocal placoid pigment epitheliopathy Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) is an acquired inflammatory uveitis that belongs to the heterogenous group of white dot syndromes in which light-coloured (yellowish-white) lesions begin to form in the macular area of the retina. Early in the course of the disease, the lesions cause acute and marked vision loss (if it interferes with the optic nerve) that ranges from mild to severe but usually transient in nature. Classified as an inflammatory disorder that is usually bilateral and acute in onset but self-limiting. The lesions leave behind some pigmentation, but visual acuity eventually improves even without any treatment (providing scaring doesn't interfering with optic nerve). It occurs more commonly in females, and is more likely to affect a persons between 20–30 years of ages but has been seen in people 16 to 40 years of age . It is known to occur after or concurrently with a systemic infection (but not always), showing that it is related generally to an altered immune system. Recurrent episodes can happen, but is extremely rare. ==Etiology==
The aetiology of the inflammation remains unknown, with various theories of it occurring as an autoimmune response to a mild infection, or the possibility of it being viral because of the preceding flu-like illness that generally accompanies it.〔〔 It is usually associated with HLA-B7 and HLA-DR2
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